147P Changes in demographic and smoking history trends in patients referred to a London thoracic malignancy specialist centre between 2010–2021: The Guy’s Cancer Centre experience

In the UK it is estimated that 10–15% of lung cancer cases occur in never-smokers. This study demonstrates changes demographic characteristics, including smoking status, all patients referred to thoracic malignancy unit at Guy’s Cancer Centre, South East London, between 2010 and 2021. We included with a documented ICD10 diagnosis bronchus who were from until A total 6861 identified. collected baseline clinical status socio-economic for patients. Descriptive statistics utilised highlight dynamic over years The number referrals per year remained overall stable 2019, decrease 2020 2021, most likely due COVID-19 pandemic. observed gradual increase percentage never smokers among patients: 5%, 8%, 10% 13% 2010, 2015, 2018 2021 respectively. Median age across (range 68–71 years). Male was 56%, 55%, 53% From we had ethnic background proportion White/Black/Asian/Other or Mixed ethnicity median 87%, 7%, 3%, 3% common histological adenocarcinoma, followed by squamous cell carcinoma small carcinoma. never-smoking related has gradually increased There little variability age, sex background. Never-smoking distinct biological entity, therefore, further research should focus on understanding aetiology risk factors leading development cancer, absence history tobacco exposure.